Showing posts with label goldenseal. Show all posts
Showing posts with label goldenseal. Show all posts

Tuesday, August 2, 2016

Herbal Constituent Kills Hospital Acquired Candida and It's Biofilm State

In the last post, I mentioned that western medicine is waking up to the realization that herbs may be the answer to the antibiotic resistant infectious diseases we created. Today, I will share a new research study with you that examines an herbal constituent called berberine. 

Berberine is found in Goldenseal - Hydrastis canadensis, Oregon grape and other species of Berberis  Phellodendron amurense, Gold thread - Coptis chinensis. Many of the antimicrobial, antifungal, antiparasitic actions of these herbs have been attributed to this one constituent. However, as I mentioned in the previous article, the whole herb is still necessary. We discussed how Berberis has a metabolite called 5-methoxyhydnocarpin-D (5'-MHC) that is needed for berberine to be more fully effective . 5'-MHC is a natural plant inhibitor of multidrug resistant pumps.  Although 5'-MHC has no antimicrobial activity of its own, the constituent berberine is much more effective when given in conjunction with the substance. 

So, this new research looks at the antifungal activity of berberine in fluconazole-resistant pathogenic yeasts. They specifically were looking at candida that is acquired in the hospital. This was really nasty hard to treat candida. Fluconazole is a fairly strong antifungal drug that use to work on candida but now there is the fluconazole-resistant candida that hospitals have bred and is living on equipment and various devises used in surgical procedures.

Basically, the study found that berberine not only killed the free floating candida planktonic yeast cells but also the biofilm forming cells. Since many biofilms are resistant to conventional antifungal agents this is exciting news to the researchers.

The Brief Details
This study exposed the candida to berberine and found it  caused loss of cellular membrane integrity resulting in cell membrane permeability and decreased the number of viable cells.
According to the data obtained in this study, berberine causes the death of fluconazole-resistant Candida spp. cells by apoptosis (cell suicide).

The results of this study showed that the berberine concentration necessary to inhibit both planktonic cells and preformed biofilm cells is similar. This indicates that berberine may reduce the growth of planktonic cells and inhibit the viability of cells in preformed biofilms at concentrations of 8 μg/ml and 37.5 μg/ml, respectively. This finding is relevant because biofilms are frequently associated with reduced sensitivity to conventional antifungal agents.

Hopefully, when used internally, they will know enough to use berberine in a whole plant base of Berberis spp.

Wednesday, May 23, 2012

Herb Class May 6th

My goodness we looked at a lot of different herbs during this class. We did not take photos but I have some I took before and after class that will help you to remember most of the plants we saw this May. I have also noticed that those of you receiving this blog by email are still getting the words rearranged and the photos are out of place. You might come direct to the blogsite to read these blogs so you get the original typeset.

Echinacea tincture in bottles
We started class by filtering our Echinacea purpurea tincture and everyone got to take some home with them. We also pressed out our vinegar extract started from the prior class and added dried ginger and nettle to it.





As soon as we were done with our inside fun, we moved outside to enjoy the sunshine and look at herbs. 

Herb Walk

Celandine flower
 We looked at Greater Celandine - Chelidonium majus which was in flower. We examined the bushy plant and noted that when you break the stem an orange colored sap oozes out. This sap has escharotic activity. This means it eats away at tissue. It is used to eat away warts. This plant is in the same family as Bloodroot that we saw last week and the Opium poppy. That family is Papaveraceae. Although it has been used historically for liver disease, we discussed the cases of cholestatic hepatitis that has taken place with this plant and the possibility that it might be more of a choleretic than cholagogue which might cause  a problem for folks if they don’t use an additional cholagogue with it. However, it is best for folks who are not a skilled practitioner to simply not use this plant internally. This plant is also an ingredient in the injectable cancer medicine called Ukraine.

Angelica archangelica spring
We collected quite a few roots. We dug up some Angelica archangelica, Geranium root, Poke root and Yerba mansa root. We also collected some Plantain.  We took our roots inside and cleaned them.


Angelica early summer



The Angelica archangelica, Geranium maculatum and Yerba mansa are all drying as well as the plantain.

Angelica - Angelica archangelica is a wonderful carminative that not only helps with gas but is also useful as an antimicrobial and antispasmodic in food poisoning formulas. It also makes a pleasant addition to cough formulas as an expectorant and antimicrobial.

Geranium late spring



Geranium - Geranium maculatum is a strong astringent. I know you all know what astringents do in detail and won’t go over that again. This is one of my favorite astringents although there are so many at our beck and call.

Yerba mansa - late spring

Yerba mansa - Anemopsis californica is so darn good smelling. I just can’t get enough of the smell of those roots.  Another astrinent but also anti-inflammatory, antibacterial, antifungal and a diuretic. It is wonderful in sore throat formulas of both viral and bacterial nature.

Plantago lanceolata
Plantain - Plantago laceolata and major is such a fantastic herb. It is healing to the skin and mucous membranes. It is my favorite herb to use as a healing spit poultice. I put it in healing salves and use it internally any time I want to heal up an irritated mouth, throat or gut. It is also soothing to the urinary tract. It is an all around wonderful vulnerary. It will decrease inflammation and has some direct antibacterial action.

Poke - spring
The Poke root - Phytolacca decandra (americana) went into olive oil to make a Poke oil and the other roots are drying on drying racks. There are photos of them drying at the end of this blog. The Plantain is also drying and will be used as part of a healing salve that we will make in another month or two. As always, we tasted the roots to get better aquainted with the plants.

Poke in oil heating slowly
Poke oil filtering
We discussed that Poke is a low dose botanical and can be toxic so only trained professionals should use this plant. Poke root oil is used externally for mastitis and over enlarged lymph nodes. The root is also used internally in small doses as a lymphogogue. Practitioners use it as a lymphagogue in cancer protocols as well as for acute and subacute infectious conditions with lymphatic stagnation and enlarged lymph nodes. We discussed specific situations it is used in such as strep throat. Poke is specific for hard enlarged lymph nodes.

We took another look at Bloodroot to see what it looks like as it is growing. 

Goldenseal flower
Goldenseal - Hydrastis canadensis was also up. It is growing in the same bed as the bloodroot as they both like to grow in 75% shade. The Goldenseal was starting to bloom. Goldenseal is bitter,  astringent, antimicrobial, laxative, styptic and adrenolytic. It contains berberine which is the same constituent we talked about for way too long when we looked at Oregon Grape.

Cramp bark flowering
The Cramp Bark - Viburnum opulus 
Cramp bark bush
was blooming. The bark of this large bush is a wonderful nervine. It is a very strong antispasmodic. Although best known for use in menstrual cramps, it is useful for all manner of spams be they of skeletal muscle tissue or smooth muscle fibers. This means it helps with stones causing gall bladder spasms and ureter spasms as well as spastic muscles when you tweak your back.  It relaxes the muscles in your arteries thereby lowering blood pressure and yes it does relax the uterus when it is spastic so it has been used in menstrual cramps and threatened miscarriage due to spasms and premature contractions. After labor its ability to act as an astringent helps restore normal tone and prevent uterine prolapse. I think the plant is under utilized. It’s fruits are antioxidant and high in vitamin C and flavonoids. They have also been shown to have gastrodudodenal protective effects. The berries have been shown to increase super oxide dismutase and glutathione peroxidase.

Wild ginger flower
I just love seeing the Wild Ginger - Asarum caudatum blooming. It is gorgeous. I pointed it out to everyone as it is one flower you just do not want to miss. I warned folks that the roots contain aristolochic acid and so it should never be used except in very small amounts if at all. It does have a ginger taste to it and many have used it for its flavor as well as its medicinal effects but due to it having the possible side effect of damaging your kidneys, I suggest folks just admire its beauty.

back of leaf on Cascara

front of leaf on Cas
We examined the Cascara - Rhamnus purshiana by the creek. We discussed the use of Cascara bark the week before but did mention once again that it is a strong purgative laxative and should be dried and aged one year before using.






Istatis tinctoria











The Isatis tinctoria was blooming. This herb is used in Chinese medicine a lot. It seems to be their go to herb for both viral and bacterial sore throats and other infections of a contagious nature according to Michael and Lesley Tierra. If you are interested in Chinese herbal medicine I suggest you get their book called Chinese Traditional Herbal Medicine Volume II – Materia Medica and Herbal Resource. Both the leaf parts as well as the roots are used. I have not tried this plant myself yet but intend too soon. You can get their book directly from them at their website here.

Sterile horsetail shoot
Horsetail - Equisetum arvense was at the perfect stage for harvesting. I missed getting it this year. Darn! It is a great source of soluble silica, but you have to get the sterile shoots before they get very big. They should look like they do in this photo. Don’t bother harvesting them when they are bigger as the silica will not be soluble and useful any more. This soluble silica is helpful for growth of bones, cartilage, hair, nails, and skin.  Horsetail is also a diuretic and astringent and is used sometimes in urinary tract problems where there is passive bleeding such as gravel or inflammatory bacterial infections. Don’t take too much horsetail without taking vitamin b1 (thiamine) as it contains thiaminase and can deplete thiamine when used long term.

Caraway in bloom
Caraway - Carum carvi was also blooming. This spicy and aromatic seed is used as a carminative, antispasmodic and galactagogue.












Blueberries
Blueberry/Bilberry/Huckleberry - Vaccinium spp.
We looked at the blueberries. (Remind me I need to show you the huckleberries next class.) These plants, especially the berries are high in anthocyanins. Anthocyanins have more research on them than you can shake a stick at. Basically they are strong antioxidants and perform a great job stabilizing collagen, and maintaining elastin. This supports connective tissue which is found all through-out our body as the most abundant tissue in our bodies.

The leaves are high in chlorogenic acid. Plants with clorogenic acid  seem to be all the rage as a diet aid nowadays.

So, you won't be surprised to find out this group of plants has a wide range of uses. The leaves have a history of being used as a hypoglycemic and recently there has been research showing the berries may also be hypoglycemic. This sheds light on why so many diabetics have reported being able to eat them. They do contain sugar so I always warn diabetics to be cautious if they try eating them. Research does show that a diet rich in blueberries decreases the chance of both cardiovascular disease and diabetes. The berries are used for hyperlipidemia, protection from vascular damage, easy bruising, enhancement of cognitive abilities, hypertension, neurodegeneration, rheumatoid arthritis, obesity and the list just goes on and on. The leaves are astringent and as such can cause gastrointestinal irritation if ingested in excess. This is similar to black tea which is also astringent.

If you grow your own blueberries or you pick at a local organic farm, you can preserve them by either drying or freezing the berries. Both methods will maintain the anthocyanin content. This way you can eat these tasty treats all winter long!

I also have some photos of various things drying. Here they are:


Yerba mansa before cutting it up.
Yerba mansa on top and geranium on bottom


Geranium roots prior to cutting up

Plantain drying



























It has been so long since class that I probably forgot some of the things we looked at. I know we discussed Osha but I did not take any photos and we saw quite a few additional things at the creek. Sorry, I did not get them all posted here. Wait until you see how much we have to look at next class. All the plants are delighting in the rain and warm weather and growing… well like weeds.

See you all soon. Take good notes at our summer classes and bring your camera as I will not be posting notes much the rest of the summer.